Anastrozole is a powerful third generation nonsteroidal aromatase blocker.
Anastrozole is an aromatase inhibitor (AI) drug designed to decrease the circulation of estrogen in the blood plasma and stimulate the production of endogenous testosterone and gonadotropic hormones.
Aromatase inhibitors belong to an even broader class of drugs known as antiestrogens.
Anastrozole is used as an adjunct treatment for breast cancer. It is the most popular aromatase inhibitor among bodybuilders who use anabolic steroids to control estrogen.
Helps get rid of estrogenic side effects: manifestation of gynecomastia, water retention and bloating, hypertension (due to water retention, increased estrogen).
Studies have shown that men’s use of anastrozole was effective enough to reduce plasma estrogen levels by 50%, only at a dose of 0.5-1 mg per day.
Anastrozole and letrozole are classified as non-steroidal and non-suicidal aromatase inhibitors that compete with the substrate for binding to the active sites of the enzyme.
Bodybuilders and athletes who take anabolic steroids generally prefer aromatase inhibitors such as anastrozole for their ability to reverse the rise in estrogen levels from the root cause: aromatase.
Via the aromatase enzyme, supraphysiological levels of aromatized androgens (such as testosterone, danabol, boldenone, etc.) cannot be converted to estrogen, eliminating any possible risk of estrogen-related side effects.
Athletes use this type of drug during an anabolic androgenic steroid cycle for:
- Warnings for gynecomastia;
- Increase the amount of anabolic hormones in the blood;
- Impact improvements;
- Normalization of blood pressure.
An increase in the dosage of the drug can excessively lower estrogen levels and lead to the following undesirable manifestations:
- Slower muscle development
- Articolar pains;
- Fragility of the bones;
- Increased cholesterol level;
- Intolerance to the components of the drug;
- Heart failure;
- Hepatic or renal insufficiency;
- Pregnancy and breastfeeding;
- Combination with medicines containing estrogen or tamoxifen;